Williams et al. (19) studied the effect of recombinant human IFN-aA on the pharmacokinetics of antipyrine. Following a single intramuscular dose of IFN-aA in nine patients, antipyrine clearance was found to be decreased. The decrease was variable, ranging from 5% to 47%.
In another study, the same authors (20) studied the effect of IFN-aA (single intramuscular dose) on theophylline clearance in five patients with stable chronic active hepatitis B and four healthy subjects. Like antipyrine, theophyl-line clearance was reduced and varied from 31% to 81% in eight of nine patients. In one patient, no change in theophylline clearance was observed.
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