Recombinant Human InterferonaA

Williams et al. (19) studied the effect of recombinant human IFN-aA on the pharmacokinetics of antipyrine. Following a single intramuscular dose of IFN-aA in nine patients, antipyrine clearance was found to be decreased. The decrease was variable, ranging from 5% to 47%.

In another study, the same authors (20) studied the effect of IFN-aA (single intramuscular dose) on theophylline clearance in five patients with stable chronic active hepatitis B and four healthy subjects. Like antipyrine, theophyl-line clearance was reduced and varied from 31% to 81% in eight of nine patients. In one patient, no change in theophylline clearance was observed.

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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