Screening Tools For Intranasal Formulation Development

The successful development of IN products necessitates robust screening tools predictive of PK performance in humans. Early in the development process, the capability for high-throughput screening (HTS) is important, particularly for peptide and protein formulation development requiring optimization among many product attributes such as permeation enhancement, drug stability, and other properties. The discussion below provides an overview of the in vitro and in vivo models available to guide IN product development.

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