Wt

209 ± 11 nM

0.5 ± 3d

121 ± 16 hr

0.8 ± 0.2 mUhr/kg

PK study in

(62,63)

FcRn mutant P257I/Q3111

2.6 ± 0.5 nM

7 ± 2d

114 ± 9 hr

0.9 ± 0.1 mUhr/kg

cynomolgus

Target: TNFa

FcRn mutant T250Q/M428L

5.2 ± 0.1 nM

0.7 ± 0.1d

112 ± 11 hr

0.9 ± 0.4 mUhr/kg

monkeys

Datta-Mannan et al.

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