Acknowledgments

This work was supported by grants from the European Commission (FP-6 Integrated Project LSHG-CT-2003-503259), the Russian Academy of Sciences Program in Molecular and Cell Biology, the Russian Foundation for Basic Research (Project 07-04-12189), the National Institutes of Health (GM070358), and the Howard Hughes Medical Institute grant HHMI 55005618.

References

1. Droge, W. (2002) Free radicals in the physiological control of cell function. Physiol Rev 82, 47-95.

2. Crow, J. P. (1997) Dichlorodihydrofluo-rescein and dihydrorhodamine 123 are 5. sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide 1, 145-157.

3. Marchesi, E., Rota, C., Fann, Y. C., Chignell, C. F., and Mason, R. P. (1999) 6. Photoreduction of the fluorescent dye 2'-7'-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measure- 7.

ments. Free Radic Biol Med 26, 148-161.

4. Rota, C., Fann, Y. C., and Mason, R. P. (1999) Phenoxyl free radical formation during the oxidation of the fluorescent dye 2',7'-dichlorofluorescein by horseradish peroxidase. Possible consequences for oxidative stress measurements. J Biol Chem 274,28161-28168.

Belousov, V. V., Fradkov, A. F., Lukyanov, K. A., Staroverov, D. B., Shakhbazov, K. S., Terskikh, A. V., and Lukyanov, S. (2006) Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat Method 3, 281-286.

Zheng, M., Aslund, F., and Storz, G. (1998) Activation of the OxyR transcription factor by reversible disulfide bond formation. Science 279, 1718-1721. Choi, H., Kim, S., Mukhopadhyay, P., Cho, S., Woo, J., Storz, G., and Ryu, S. (2001) Structural basis of the redox switch in the OxyR transcription factor. Cell 105, 103-113.

Was this article helpful?

0 0

Post a comment