Food Allergy Survival Guide

Food Allergies

Food Allergies

Peanuts can leave you breathless. Cat dander can lead to itchy eyes, a stuffy nose, coughing and sneezing. And most of us have suffered through those seasonal allergies with horrible pollen counts. Learn more...

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The Fc2 3PE40 chimeric protein a possible treatment for allergy responses

About 20 of the world population suffers from various allergic diseases such as asthma, allergic rhinitis, food allergies, atopic dermatitis and anaphylaxis. The alarming increase in the prevalence of these diseases over the past decade has led to a clear need for more effective therapeutic strategies.

Brief Mechanism About Asthma

FceRI is located on the surfaces of basophils and mast cells, which act as effector cells in IgE-mediated immune responses (Kinet, 1990). FceRI is composed of four subunits one p-chain, one a-chain, and two disulfide-linked g-chains. Most of the a-chain extends into the extracellular region, where it binds directly and with high-affinity to the Fc portion of IgE antibodies thus, the a-chain is the most important component of the FceRI molecule (Hakimi et al., 1990). The cross-linking of FceRI with allergen-IgE complexes causes the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins from activated basophils and mast cells, which contributes to the allergic responses in asthma, atopic dermatitis, allergic rhinitis, and food allergies (Drombrowicz et al., 1993 Gauchat et al, 1993 Metzer, 1991 Yanagihara et al., 1997).

Ethnicity As A Starting Point For Pharmacogenetic Investigation

Issues is provided by the analysis of lactase nonpersistence (lactose intolerance). Lactase nonpersistence is a genetically unusual autosomal recessive trait that is determined by a polymorphic gene (LCT) as described in Appendix A. LCT is located on chromosome 2q21.83,84 For many years efforts to find LCT variants responsible for lactase persistence proved fruitless but it was suggested that a c s-acting element contributed to this phenotype.85,86 In 2002 a breakthrough occurred when a C T single nucleotide polymorphism (SNP) located in the 13th intron of a completely different gene, MCM6, was found to be strongly associated with the trait in Finnish families.84 Sequence analysis of the complete 47-kb region of interest and association analysis revealed that a SNP DNA variant, C T-13910, approximately 14 kb upstream of but separate from the LCT locus, was completely associated with lactase nonpersistence. A second variant, G A-22018, 8 kb telomeric to C T-13910 was also associated...

Botanical Polysaccharides as Adjuvants

In contrast to the adjuvant properties described previously botanical polysaccharides have, in some cases, been reported to attenuate immune responses and have been proposed as promising agents for the treatment of IgE-dependent diseases (e.g., atopic dermatitis, asthma, atopic rhinitis, urticaria and food allergies). For example, Danilets and co-workers 297 studied the effects of water-soluble polysaccharides isolated from six different plants on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunised with OVA. They found that treatment with polysaccharides from coltsfoot, sweet flag, clover, Artemisia, marigold and elecampane reduced animal mortality after induction of anaphylactic shock. In addition, injection of these polysaccharides reduced serum concentrations of IgE and IgG1 297 . Likewise, pectins have been reported to exhibit antiallergic activity, resulting in a suppressed allergic asthmatic reaction in animals treated with doses of 5-12 mg kg...

Pre Ketogenic Diet Session

Food allergies, intolerances, and cultural and religious preferences require special consideration and may necessitate adjustments in the diet. Information regarding current medications and nutritional supplements is needed to determine appropriateness to the diet. Medications and supplements in suspension, syrup, elixirs, and chewable-tablet forms generally contain concentrated sources of carbohydrate, and alternatives should be used. A 3-d food diary is also recommended prior to ketogenic diet initiation to determine the child's dietary practices, food preferences, and method of nutritional intake. The ketogenic diet can be formulated for oral intake, enteral intake, or a combination of these methods.