References

N. (2001). Physiology of the GABA and glycine systems. In Pharmacology of GABA and Glycine Neurotransmission (H. Mohler, Ed.), pp. 3-76. Springer-Verlag, Berlin. Alves, N. D., de Castro-Costa, C. M., de Carvalho, A. M., Santos, F. J., and Silveira, D. G. (1999). Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. Arq. Neuropsiquiatr. 57, 916-920. Andree, T., Kendall, D. A., and Enna, S. J. (1983). THIP analgesia Cross...

Sensory Pathways and GABA

The transmission and perception of pain are complex processes involving both the central and peripheral nervous systems. In general, pain impulses are generated, propagated, and sustained by the liberation of various autocoids, ions, and neurotransmitters at various points between the site of tissue damage, along the afferent sensory fibers, and within the spinal cord and brain. Some endogenous agents, including adenosine and a variety of neuro-peptides, are responsible for initiating,...

N H

FIGURE 1 Structures of the GABAA agonist partial agonist THIP, the GABAA partial agonist antagonist Thio-THIP, and the GABAc antagonist Aza-THIP. as an agonist by a distinct subpopulation of GABA receptors, which was named GABAb receptors (Bowery et al., 1980). Cloning of the GABAbR1 and GABABR2 receptors and the identification of functional heterodimeric GABAB receptors have greatly stimulated GABAB receptor research (Martin et al., 1999 Mohler and Fritschy, 1999). The classical BMC-sensitive...

A GABAa Receptor Agents

The most definitive data supporting a role for GABA in the transmission and perception of pain are derived from pharmacological studies. In general, both clinical and preclinical experiments indicate that agents known to enhance GABAergic transmission display antinociceptive activity (Bowery and Enna, 2000 Dirig and Yaksh, 1995 Hill et al., 1981 Johnston, 1992 Kaneko and Hammond, 1997 Kendall et al., 1982 Kjaer and Nielsen, 1983 Malan et al., 2002 Rode et al., 2005 Vaught et al., 1985 Zorn and...