Other Products Monographs

FUTURE DIRECTIONS 337

13 Advanced Drug Delivery 339

13.1. Rationale and Basic Principles 339

13.2. Physiologic and Mechanistic Approaches 345

13.3. Approaches Using Devices 367

13.4. Molecular Approaches 369

13.5. Summary 374

14 Individualization of Drug Regimens: Integration of Pharmacokinetic and Pharmacogenetic Principles in

Drug Therapy 381

14.1. Overview of Factors Governing Interindividual Variations 381

14.2. Historical Perspective on Pharmacogenetics 382

14.3. Pharmacogenetics: Drug Metabolism and Transport 386

14.4. Pharmacogenetics: Therapeutic Response 391

14.5. Individualized Gene-Based Medicine: A Mixed Blessing 395

14.6. Current and Potential Application of Pharmacogenetics 396

14.7. Summary 398

15 Gene and Cell Therapy 401

15.1. Overview of Gene and Cell Therapeutics 401

15.2. Delivery and Expression of Genes Encoded for Functional Proteins 412 Sean M. Sullivan

16 Integration of Discovery and Development: The Role of

Genomics and Proteomics 427

16.1. Overview 427

16.2. Integration of Discovery and Development of Therapeutic

Candidates 429

16.3. Genomics: The First Link between Sequences and Drug Targets 430

16.4. Proteomics: From Sequences to Functions 433

16.5. Integrating Proteomic and Genomic Tools to Accelerate Drug Development 437

16.6. Summary 443

Appendix I Dosage Form, Pharmacokinetics, and Disposition Data 445

Appendix II Molecular Characteristic and Therapeutic Use 467

Appendix III Nomenclature of Biotechnology Products 495

Appendix IV Synonyms of Trade, Common, and Scientific Names 499

Appendix V Other Information Tables 527

Index 539

Monographs Index 555

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