Biomarkers Used to Characterize Effects Caused by Boron

Central nervous system injury, gastrointestinal effects, and skin damage are characteristic manifestations of boron toxicity in humans. Liver and kidneys in humans and testes in animals can also be affected. Various clinical and biochemical changes associated with these effects may be measured to detect the extent of exposure to boron. There is no single biological indicator of boron exposure consequently, several parameters must be measured including boron levels in urine and blood and...

Oral Exposure 2221 Death

Studies in humans, particularly infants, show that boron (as boric acid) can be lethal following ingestion. Infants who ingested formula accidentally prepared with 2.5 aqueous solution of boric acid died within 3 days after exposure (Wong et al. 1964). It was estimated that the amount of boric acid consumed ranged from 4.51 to 14 g. Although 5 of 11 infants died, the authors provided histopathological data and weights for only 2 infants who had ingested 9.25 g (505 mg boron kg day) and 14 g...

Systemic Effects

No studies were located regarding respiratory effects in animals or cardiovascular or musculoskeletal effects in humans or animals after oral exposure to boron. Information on respiratory, gastrointestinal, hematological, hepatic, renal, and dermal ocular effects is discussed below. The highest NOAEL values and all reliable LOAEL values for these systemic effects for each species and duration category are recorded in Table 2-2 and plotted in Figure 2-2. Respiratory Effects. Widespread vascular...

Relevance To Public Health

Estimates of levels of exposure to boron posing minimal risk to humans (MRLs) have been made. These are discussed in Section 2.2 and were based on data believed to be reliable for the most sensitive noncancer effect for each route and exposure duration. No data were located on effects of acute-duration inhalation exposure in humans or animals nor on intermediate-duration inhalation exposure to boron in humans. Available information on intermediate-duration inhalation exposure in animals and...