Systemic Effects

No studies were located regarding respiratory effects in animals or cardiovascular or musculoskeletal effects in humans or animals after oral exposure to boron. Information on respiratory, gastrointestinal, hematological, hepatic, renal, and dermal ocular effects is discussed below. The highest NOAEL values and all reliable LOAEL values for these systemic effects for each species and duration category are recorded in Table 2-2 and plotted in Figure 2-2. Respiratory Effects. Widespread vascular...

Reproductive Effects

No studies were located regarding reproductive effects in humans after oral exposure to boron. Animal studies demonstrated that boron can cause injury after intermediate and chronic exposure to the gonads in animals, especially the testes. Impaired spermatogenesis has been reported in rats administered 300 mg boron L as borax (44.7 mg boron kg day) in drinking water for 70 days (Seal and Weeth 1980), but no reproductive effects were evident in rats administered up to 6 mg boron L of borax (0.6...

Relevance To Public Health

Estimates of levels of exposure to boron posing minimal risk to humans (MRLs) have been made. These are discussed in Section 2.2 and were based on data believed to be reliable for the most sensitive noncancer effect for each route and exposure duration. No data were located on effects of acute-duration inhalation exposure in humans or animals nor on intermediate-duration inhalation exposure to boron in humans. Available information on intermediate-duration inhalation exposure in animals and...