Help For Hearing Loss Sufferers

Hearing Sense Recovery

This product was created by Mark after he had gone through an experienceof getting his wife's hearing back. He was contacted by one of the most brilliant researchers on the topic of getting one's hearing back and he was able to conduct a research with him in the African tribes in Kenya, the superfoods they have used have made them become the country with the least hearing loss in the world. They have made an experiment on Mark's wife who was able to get her hearing back in merely three weeks. After that, Mark has decided to put the information out to the world so they can help their hearing and the hearing of their loved ones to finally experience life as it truly should. He put the information into an easy step by step guide that walks you through every single phase you have to go through to improve the hearing. The method is very easy to attain and it does not need any technical knowledge, you can easily get this product and you will be able to get your hearing back in just three weeks. The method that is used is also natural and safe and it definitely works no matter how bad the hearing condition is, it will heal and strengthen the cells responsible for hearing. More here...

Hearing Sense Recovery Summary

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Improve Your Hearing Naturally

What You'll Find Inside Improve Your Hearing Naturally: What Supplements Vitamins and Herbs You Need To Be Taking Right Now To Stop Hearing Loss, Restore Your Hearing and Open Up Those Muffled Ears . In Fact If You Missing These Nutrients In Your Diet Your Hearing Will Continue To Decline. How To Unblock And Clean Out Years Of Built Up Toxins From Your Ears and Ear Canals Instantly Improving Your Hearing! No More Muffled Hearing, How Would You Like To Hear Out Of Both Ears Equally? - Most People Are Completely Shocked When They See What Comes Out Of Their Ear Canals. Learn The Best Natural Home Remedies For Ear Infections, Ear Blockage, Ear Aches, Ringing In The Ears (Tinnitus) And Other Ear Problems - Plus How To Properly Clean Your Ears, Safely With No Risk Of Damage. Discover What Common Drugs Every Home Has In Their Medicine Cabinet You May Be Taking That Can Permanently Damage Your Hearing - Doctors Don't Tell You This And You Need To STOP Immediately

Improve Your Hearing Naturally Summary

Official Website: improvehearingnaturally.com

The New Frontier Systems Biology

Of note, genetic modulation of pain is not limited to the nuclear genome. Several human diseases (e.g. cardi-omyopathy, neuropathy, deafness) are caused by mito-chondrial gene mutations. In addition, acquired deficiencies in mitochondrial function are thought to lead to some forms of neuropathy.

Pulmonary Arterial Hypertension

SILDENAFIL (Revatio) Pulmonary arterial hypertension 20 mg PO tid. Contraindicated with nitrates. Coadministration is not recommended with ritonavir, potent CYP3A inhibitors, or other phosphodiesterase-5 inhibitors. Teach patients to seek medical attention for vision loss, hearing loss, or erections lasting longer than 4 h. Trade only (Revatio) Tabs 20 mg. LK 2B TADALAFIL (Adcirca) Pulmonary arterial hypertension 40 mg PO daily. Contraindicated with nitrates. Coadministration is not recommended with potent CYP3A inhibitors (itraconazole, ketoconazole), potent CYP3A inducers (rifampin), other phosphodiesterase-5 inhibitors. Caution with ritonavir, see PI for specific dose adjustments. Teach patients to seek medical attention for vision loss, hearing loss, or erections lasting longer than 4 h. Trade only (Adcirca) Tabs 20 mg. L 2B

HT2CR Mutant Mice as a Model of Audiogenic Seizure Disorder

Two aspects complicate interpretation of this seizure phenotype. First, the constitutive 5-HT2CR - Y mice studied all retain some DBA 2 genetic loci. Mice of strain DBA 2 are known to have increased susceptibility to seizures. However, DBA 2 mice show this tendency early in their life, and seizure susceptibility loci identified within this strain are autosomally located. Furthermore, constitutive 5-HT2CR - Y mice backcrossed five to eight times onto a pure C57BL 6 background continued to demonstrate phenotypic differences in susceptibility to olfactory bulb kindling, chemoconvulsant, or corneal electroshock evoked seizures (Applegate and Tecott 1998). These findings suggest that contributions from the DBA 2 strain were not significant factors influencing the seizure phenotype observed in constitutive 5-HT2CR mutant mice. Additionally, C57BL 6 J mice are known to have a well-described phenotype of middle-aged high frequency hearing loss. Microelectrode recordings of inferior colliculus...

Clinical Aspects Of Bacterial Meningitis

Recently, high-resolution MRI was used to demonstrate inner ear involvement in adults with bacterial meningitis.1 The structures most frequently involved were the cochlear nerve, the first cochlear turn, the vestibulum and the semicircular canals. There was a significant correlation between clinical and MRI findings all patients with cochlear enhancement were deaf (hearing loss, 90 dB), whereas none of the patients with normal MRI findings had hearing loss of more than 90 dB. This study shows that high-resolution MRI can visualize involvement of vestibulocochlear structures in bacterial meningitis, in both cooperative and consciously impaired patients. These findings suggest a correlation between abnormalities on MRI and the extent of cochlear dysfunction.

The Medical History of Current TB Chemotherapy

Effective chemotherapy for tuberculosis began in 1940s with the discovery and use of streptomycin (STR, Fig. 1 1a) and para-aminosalicylic acid (PAS, Fig. 1 2a) 7-9 . The first randomized controlled study of STR treatment for TB by the British Medical Research Council (BMRC) showed that streptomycin was effective in the short term but that ultimately so many patients developed STR-resistant TB and hearing loss that at 5 years, no net clinical benefit was seen 10 . Contemporaneously, PAS was found to be bacteriostatic against MTb (including STR-resistant strains) in experimental models and able to prevent the development of STR

Overview of Central Nervous System CNS Bacterial iNfECTioNs

Bacterial infections can be generally subdivided into two categories based on the anatomical location of lesions. Bacterial meningitis, as the name implies, involves infection of the subarachnoid space and can be caused by a wide array of organisms. Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae are among the leading etiologic agents of community-acquired meningitis in humans.12 Despite advances made in vaccination and treatment strategies, bacterial meningitis remains associated with a significant mortality rate and incidence of neurological sequelae, particularly in very young and elderly patients. Long-term effects resulting from meningitis include hearing loss, hydrocephalus, and sequelae associated with parenchymal damage including memory loss, cerebral palsy, learning disabilities, and seizures.34 Bacterial meningitis elicits a complex myriad of pathophysiological changes, many of which have been attributed to an excessive host antibacterial immune...

Hh And The Gonadotropinreleasing Hormone Receptor

IHH is a disorder characterized by a complete or partial lack of sexual development that may be either congenital or acquired 146, 147 - IHH is a rare disease, with estimated incidence of 1 10,000 to 1 86,000 147 . Patients afflicted with IHH have a deficient pituitary gonadotrope response to gonoadotropin-releasing hormone (GnRH), which results in reduced or apulsatile gonadotro-pin release, delayed onset or absence of puberty, and infertility (for review, see References 4, 146, 147). IHH patients may also present with a variety of anomalies, such as anosmia hyposmia, which is usually diagnosed as Kallmann syndrome, cleft palate, dental agenesis, visual abnormalities, deafness, and mental retardation, among others 146 . The disease may present at birth, adolescence, or adulthood. IHH is genetically heterogeneous, with X-linked recessive, autosomal recessive, autosomal dominant, and apparent sporadic inheritance patterns. Mutations in one of three genes are most commonly associated...

Mechanism Of Audiogenic Seizures

E., and Faingold, C. L., Developmental hearing impairment and audiogenic seizure (AGS) susceptibility in the genetically epilepsy-prone rat, Soc. Neurosci. Abstr., 15, 46, 1989. Willott, J. F. and Henry, K. R., Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice, J. Comp. Physiol. Psychol., 90, 373, 1976.

Disorders Of Emotional Experience And Communication

In the context of the aprosodies, we note that claims have been advanced for the existence of transcortical sensory, transcortical motor and mixed transcortical aprosodies as well as conduction aprosody and pure affective deafness, parallel to those of the aphasias.37,52 However, few convincing cases have been reported, and the existence of these conditions has not as yet gained wide acceptance. It is possible that cases have not been widely recognized and reported because they have not been systematically sought by clinicians and are not readily apparent to patients.

The renal and inner ear ClCK channels

Mutations affecting only ClC-Ka have not been implicated in human diseases so far, but simultaneous mutations in ClC-Ka and ClC-Kb lead to Bartter syndrome with deafness (see below). Even if the physiological role of ClC-Ka in humans is not completely clear, Human mutations in the -subunit barttin lead to Bartter syndrome type IV characterized by both severe renal salt loss and congenital deafness (Birkenh ger et al. 2001). According to the mechanism proposed to explain the physiopathology of the deafness, ClC-Ka and -Kb represent essential basolateral exit pathways to keep internal Cl- concentration at a level that is compatible with the efficient accumulation of K+ into marginal cells of the cochlear stria vascularis. K+ is then secreted into the endolymph, where its high concentration (150 mM) is required for the stimulation of sensory hair cells (Jentsch 2000). Mutations involving ClC-Ka or ClC-Kb alone have not been implicated in deafness. This probably reflects the fact that...

Evaluation of Seizure Severity

Control subjects utilized in GEPR research are varied, depending upon the nature of the experiment. The most common control rats are derived from Sprague-Dawley rats by selective breeding for resistance to audiogenic seizure susceptibility.4 In studies of seizure severity, GEPR-3s, lacking the tonic trait, become control subjects for GEPR-9s. Infrequently, progeny of GEPR-9 breeders are produced that are completely nonsusceptible to audiogenic seizures. These nonsusceptible progeny become valuable controls for the study of audiogenic seizure susceptibility in GEPR-9s. In fact, two types of nonsusceptible progeny of GEPR-9s have been identified. The first lacks the peripheral hearing impairment characteristic of the GEPR which is believed to be responsible for development of the audiogenic seizure focus.2425 The second possesses the hearing deficit but lacks the deficit in norepinephrine content in the midbrain characteristic of the GEPR-9.26 Finally, because audiogenic seizure...

Cyp2e1 Cyp2b6 Cyp2c8 Cyp1a2

In mice, a low concentration of brain phospholipids was found, following continuous exposure to toluene for 30 days 78 . Furthermore, a decrease in the number of the neurons at the hippocampus, after a six-month exposure to toluene at 1500 ppm, for 6 hours daily has been ascertained. It has not yet been clarified whether these changes are due to fragmentation or inhibition of the phospholipid synthesis. People exposed to long-lasting toluene action suffer from neurological disorders 79-81 , hearing loss 82, 83 , and color recognition anomalies 84-88 . Hearing loss, following the exposure of experimental animals to toluene inhalations, is due to the toluene itself but not to its metabolites. The molecular mechanism and pathogenesis of the color recognition impediment (dyschromatopsia) that is reported to those exposed to toluene are related to the dopaminergic mechanisms of the retina cells or to the toxic demyelination of the optic nerve fibers 84-88 . The repeated...

Mitochondrial Dna Variants And Aging

Mitochondrial ATP production via oxidative phosphorylation is essential for normal function and maintenance of human organ systems, and numerous mutations of mtDNA are known to cause severe maternally transmitted diseases. A common feature in this group of inborn diseases is the involvement of some enzymes in the pathway of aerobic energy production. Thus, these syndromes are characterized by defects in organs and functions where energy supply is of more importance such as muscles, heart, eye, and the central nervous system. Besides these pathogenic mutations, other maternally inherited variants of mtDNA are present in the population. The study of such variants of mtDNA led to the identification of several mtDNA haplogroups (groups of haplotypes derived from the same mtDNA ancestor). Those present in Europe are called H, I, J, K, T, U1, U2, U3, U4, U5, U6, v, W, X, and others. It is now emerging that such variants have to be considered as ''natural'' but not necessary ''neutral'' from...

Type 2 Diabetes Mellitus

The genetics of type 2 diabetes is still unclear, although in most cases several nuclear genes appear to be involved (complex genetic disease). Recent data suggest that oxidative stress can play an important role in the pathogenesis of T2DM. Indeed, increased production of ROS and decreased levels of antioxidant enzymes and vitamins could explain, at least in part, the damage observed in a number of organs and tissues in patients affected by T2DM 59 . A number of experimental and clinical observations suggest an involvement of mitochondria and mtDNA mutations in the pathogenesis of T2DM. Indeed, in some patients affected by T2DM, the disease is associated with mtDNA mutations. It is commonly assumed that in most cases a number of nuclear genes are involved (polygenic disease). However, recent data show that mitochondrial genomes can play an important role in the pathogenesis of this disease. First, a small percentage of diabetes cases that show either type 2 or type 2 phenotype is...

Relevance of an Allosteric mDia1 Inhibitor

Finally, while there is as yet no direct link between mDia activity and the development of disease states, DRFs have been proposed as novel drug targets in cancer due to their role in regulating both the actin and microtubule cytoskeleton (Faix and Grosse 2006) and the importance of these cytoskeletal elements for mitosis and cytokinesis. mDial interacts with the tumor suppressor adenomatous polyposis coli (APC), and may serve as a scaffold for APC-mediated microtubule stabilization (Wen et al. 2004). In addition, mDial binds polycystin 2 (PKD2), a protein linked to the development of polycystic kidney disease (Rundle et al. 2004). Additional evidence for the involvement of these cytoskeletal regulators in the development of disease comes from the human DRFs, where mutations in the genes encoding hDial and hDia2 have been associated with non-syndromic deafness (Lynch et al. l997) and premature ovarian failure (Bione et al. l998). Given the role of DRFs in a number of important...

Sites of Seizure Origin

Sprague-Dawley controls that could individually or collectively promote seizures in the GEPR. Finally, two reports offer some insight into the origin of the heightened excitability of the GEPR inferior colliculus. Reigel et al.25 reported a peripheral hearing impairment in immature GEPRs that preceded the developmental onset of audiogenic seizure susceptibility and proposed that the development of the audio-genic seizure focus in the inferior colliculus was a compensatory response for reduced peripheral auditory input. Consistent with this hypothesis, transient peripheral hearing impairment induced in immature Sprague-Dawley rats by kanamycin resulted in the production of an audiogenic seizure focus that was unmasked following monoamine depletion.37

Haemophilus Influenza Type B Conjugate Vaccine

The chances of contracting the disease are about 1 in 200. Of these contractees, 60 of all patients develop meningitis, while 40 display systemic signs. Hib is a tremendous problem in daycare centers, where the risk of contracting the disease is 400 times greater than in the general population. Hib has approximately a 10 mortality rate, and one third of all survivors have some sort of permanent damage, such as hearing loss, blindness, or impaired vision. Hib can also cause a throat inflammation that results in fatal choking or ear, joint, and skin infections.

Exceptions To The Rules

Cisplatin (Fig. 2.6) is a cancer chemotherapy drug. With only 11 atoms, it is smaller and less complex than most drugs. As implied by the discussions of specificity earlier in this chapter, one might expect this to result in unwanted side effects. Indeed, cisplatin use often causes severe nausea, hair loss, weight loss (perhaps indirectly from the nausea), kidney damage, hearing loss, sometimes some nerve damage, and electrolyte disturbances. However, cisplatin was originally the only hope to extend the life of patients with many forms of cancer. Thus, the severe side effects were acceptable. Today, cisplatin is still used for some forms of cancer, often in small doses mixed with other drugs having less severe side effects.

Arenaviruses

Other strains of arenavirus in South America and Africa may produce hemorrhagic fever. Lassa fever virus infection (African strain) presents as multiorgan inflammation, hemorrhage, renal dysfunction and deafness.210 Between 30 and 66 of patients die. Fevers, facial and thoracic rash, headache, small cutaneous hemorrhages, cerebellar dysfunction and

Measles

There are three forms of encephalitis produced by measles virus. The most common form is a post-infectious encephalomyelitis characterized by the acute onset of headache, fever, stiff neck, seizures and focal deficit, usually within 14 days of rash. Mortality is about 10-20 ,222 and survivors are often left with seizure disorders, impairment of cognitive function and deafness. Pathological changes are found mainly in white matter and are indistinguishable from the inflammatory demyelination seen in fatal cases of post-vaccinial encephalomyelitis due to rabies immunization or smallpox vaccination. Measles virus is not found in the brains of patients who die of measles post-infectious encephalo-myelitis.223

Adjunctive Therapy

Recently, a meta-analysis of 11 randomized clinical trials carried out since 1988 using dexamethasone as adjunctive therapy in bacterial meningitis was performed.8 In H. influenzae-meningitis in children, dexamethasone reduced severe hearing loss overall. In pneumococcal meningitis, only studies in which dexamethasone was given early suggested protection, which was significant for severe hearing loss and approached significance for any neurologic or hearing deficit. Outcomes were similar in studies that used 2 versus more than 2 days of dexametha-sone therapy. The incidence of gastrointestinal tract bleeding increased with longer duration of dexam-ethasone treatment.

History

The story goes that on September 18, 1895, Palmer cured a janitor in Iowa of deafness by manipulating a single cervical vertebra. Palmer developed a system of manual medicine techniques based on the folk medicine tradition of bonesetters and drawing on the philosophical constructs of mesmerism and vital energy, which he termed innate intelligence.'' Illness was explained by a blockage of flow of vital energy, which in turn was caused by subluxations of the vertebrae. Chiropractic manipulation corrects those subluxations and restores the energy flow.

Concluding Comments

Channels like ASICla and ASIC3 which are expressed in nociceptive neurons, have been implicated in inflammation and in various pain processes (Mazzuca et al. 2007). Voltage dependent K+ channels are key elements in the repolarization phase and duration of action potentials, consequently they are very important in a number of physiological processes. Dysfunctions of K+ channels often correspond to diseases such as episodic ataxia (Kvl.l), cardiovascular disorders (KCNQ1, HERG), neonatal convulsions (KCNQ2, KCNQ3) and deafness (KCNQ1, KCNQ4). It is very important to find molecules that are able to selectively interact with these channels. The most important sources of such molecules are animal venoms. SAK toxins which block some Kv channels, by their original mode of action and their particular structural properties, are important additions to the currently known panel of natural Kv inhibitors isolated from other animal venoms. SAK toxins target Kv1, HERG and Kv3 channels subfamilies,...

Distribution

Administration of aminoglycosides to pregnant women may result in drug accumulation in fetal plasma and amniotic fluid. Streptomycin and tobramycin can cause hearing loss in children born to women who receive the drug during pregnancy. Aminoglycosides should be used with caution during pregnancy and only in the absence of suitable alternatives.

Untoward Effects

Hypersensitivity reactions, primarily rashes, occur in 6-8 of patients when neomycin is applied topically. Individuals sensitive to this agent may develop cross-reactions when exposed to other aminoglycosides. The most important toxic effects of neomycin are renal damage and deafness. Toxicity has been reported in patients with normal renal function after topical application or irrigation of wounds with 0.5 neomycin solution. Neuromuscular blockade with respiratory paralysis also has occurred after irrigation of wounds or serosal cavities. The most important adverse effects resulting from the oral administration of neomycin are intestinal malabsorption and superinfection.

Cranial nerve injury

Anosmia, ageusia, xerophthalmia and xerostomia may develop during or early after the treatment, but do not constitute a neuropathy in a clinically strict sense and are related to the olfactory neuron taste bud and secretory cell dysfunction.2 Serous otitis media due to eustachian tube dysfunction is the cause of early conductive hearing loss, whereas late-delayed sensorineural hearing loss results from damage to the organ of Corti with secondary acoustic nerve atrophy.57 It may develop in up to 35 of patients 1-5 years after external radiotherapy for nasopharyngeal carcinoma.58

Pagets disease

Beethoven Paget Disease

Another complaint is bone deformity, especially bending of long bones and the spine, and enlargement of bones, such as the skull. An increase in the cranium has led to the term disease of the too small hat. Deformities can lead to a variety of neurovascular symptoms, such as a vertebrobasilar artery syndrome and sometimes spinal cord dysfunction, although the latter is due more commonly to Pagetic bone stealing blood from neural tissue. Deafness, a common complication, is due to damage of the cochlear capsule. It is speculated that Paget's disease was the cause of Beethoven's deafness.

Trpml1

1.6.2.1 Hearing Extensive work in recent years has elucidated that the long-known varitint-waddler phenotype in mice is caused by mutations in the TRPML3 gene (for a review, see Cuajungco and Samie 2008 ). The varitint-waddler mouse is characterized by hearing loss, vestibular dysfunction (circling behavior, waddling), and coat color dilution. Two genetic variants Death of melanocytes in the inner ear (and other tissue), leading to the devastating Va phenotype, probably occurs through Ca overloading of the cell and or loss of the cation gradient in hair cells (Grimm et al., 2007). Va partly ameliorates this phenotype through limiting the number of channels at the plasma membrane. However, to our knowledge, similar mutations in hTRPML3, attributing to deafness and other inner ear- related disorders in humans, are unknown at the present time.

Syphilis

Tions or gummas) disease develops within 1-30 years after primary infection.129 Meningovascular infarcts,130 CNS gummas, and myelopathy131 may occur. Meningovascular syphilis is characterized by headache, fever, stiff neck, and focal neurological deficit. Seizures and cranial nerve deficits, particularly optic neuritis, facial weakness and hearing loss, may also develop. In fact, 20 of syphilis meningitis patients become deaf. Dementia and psychosis characterize general paresis, a late complication of neurosyphilis. The onset of memory loss, delusions of grandeur and dysarthria is insidious. Tabes dorsalis, another late complication, consists of lightning pains in the lower extremities and abdomen, diminished reflexes, severe loss of vibratory and proprioceptive sensation and bilateral Argyll-Robertson pupils (small, irregular pupils that do not react to light, but do accommodate).

Audiogenic Priming

Lower and higher doses of kanamycin were similarly ineffective. Interestingly, the optimal kanamycin regimen produced only a transient hearing loss as measured by auditory brainstem potential thresholds and yet this treatment was capable of inducing an audiogenic seizure focus functional at postnatal day 30. Further, this audiogenic seizure focus appeared to be permanent as every subject susceptible to audiogenic seizures at postnatal day 30 following acute monoamine depletion remained susceptible when tested at 90 d of age, again following acute monoamine depletion.

Hearing Aids Inside Out

Hearing Aids Inside Out

Have you recently experienced hearing loss? Most probably you need hearing aids, but don't know much about them. To learn everything you need to know about hearing aids, read the eBook, Hearing Aids Inside Out. The book comprises 113 pages of excellent content utterly free of technical jargon, written in simple language, and in a flowing style that can easily be read and understood by all.

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