Laxatives based on naturally occurring anthraquinone derivatives

Herbs containing anthraquinone derivatives (rhubarb, senna, frangula, cascara, aloe) are used as laxatives. A meta-analysis of 11 studies dealing with colorectal cancers and laxative use showed that use of laxatives carried an increased risk (odds ratio, 1.5 95 CI, 1.3-1.6) for colorectal cancer (Sonnenberg & M ller, 1993). A more recent and very large study among nurses in the USA found no association between colorectal cancer and laxative use (Dukas et al., 2000). The relevance of this...

Toxic effects

Aristolochic acid I purity not specified was given by infusion to 20 patients having various malignant tumours, at different dose schedules ranging from 0.1 mg kg bw per day for five days to a single dose of 2 mg kg bw. The compound was too toxic to the kidneys for further trial (Jackson et al., 1964). The so-called Stephania tetrandra powder, first introduced in a slimming regimen in a Belgian clinic in early 1990, was withdrawn from the Belgian market at the end of 1992. Altogether, 1500-2000...

International exposure estimates

In 1997, the Joint Food and Agriculture Organization World Health Organization (FAO WHO) Expert Committee on Food Additives (JECFA) performed an exposure estimate for aflatoxins (JECFA, 1998). This report summarized the results of monitoring and available national estimates of intake of aflatoxins in order to provide a framework for estimating increments in intake of aflatoxins. Estimates were based on the results of available monitoring data. Total intake of aflatoxins based on the GEMS...

Info

A procedure based on an extraction method used in Germany for the determination of aristolochic acids in botanical products has been developed and applied to a variety of botanicals and botanical-containing dietary supplements. Aristolochic acids are extracted from the sample matrix with aqueous methanol formic acid. The concentration of aristo-lochic acids in the extract is determined by gradient high-performance liquid chromatography HPLC with UV absorption detection at 390 nm and their...

References

Bauch, H.J. amp Leistner, E. 1978 Aromatic metabolites in cell suspension cultures of Galium mollugo L. Planta med., 33, 105-123 Blomeke, B., Poginsky, B., Schmutte, C., Marquardt, H. amp Westendorf, J. 1992 Formation of genotoxic metabolites from anthraquinone glycosides present in Rubia tinctorum L. Mutat. Res, 265, 263-272 Blumenthal, M., Busse, W.R., Goldberg, A., Gruenwald, J., Hall, T., Riggins, C.W. amp Rister, R.S., eds 1998 The Complete German Commission E Monographs Therapeutic Guide...