A large cohort study has revealed that HDAC1, 2, and 3 are highly expressed in prostate cancer tissues, which has been correlated with dedifferentiation and increased tumor proliferation (Weichert et al. 2008a). This study indicates a significant prognostic value of HDAC2 in prostate cancer, since the relapse-free survival time is significantly shorter in patients with increased levels of HDAC2 in tumor tissues. Moreover, HDAC8 levels have been found upregulated in prostate cancer tissue (Nakagawa et al. 2007). In addition to class I HDACs, elevated function of HDAC4 has been reported in prostate cancer: in hormone refractory tumors, HDAC4 localizes in the nucleus (in contrast to the cytoplasmic localization in primary prostate cells), which might influence tumor behavior (Halkidou et al. 2004).
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.