Hot Flash Remedy report

Hot Flash Remedy report

Heres what youll discover in The Hot Flash Remedy report: The herb from central Asia that can stop hot flashes in one week! (page 17) How your brain gets tricked into firing up the furnace and how to recalibrate it. (page 6) 7 lifestyle factors that increase your odds of suffering from hot flashes. (page 19) 9 food items that bring hot flashes on fast and furious! (page 10) The bean that actually makes hot flashes non-existent for women in other countries. (page 12) The secret ingredient in your fruit bowl that extinguishes the flame. (page 17) Why 6 meals a day are better than 3 and eating more often wont make you gain weight! (page 10) How common wildflowers hold the key to shutting down hot flashes. (page 16)

Hot Flash Remedy report Summary


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Steroidal antiestrogens

The SERMs, especially tamoxifen and toremifene, have been the preferred first-line hormonal therapy in estrogen-responsive postmenopausal breast cancer, but they have several disadvantages that are related to their partial estrogenic agonistic activity. These include tumor stimulation in some patients at the initial stages of the treatment (tumor flare) and increased hot flashes, endometrial cancer, and thromboembolism. These limitations stimulated the search for pure ER antagonists.

Menopausal Vasomotor Symptoms

In addition to its proven efficacy in PMDD, paroxetine (20 mg day) was shown to be effective in the treatment of postmenopausal hot flashes in breast cancer survivors with chemotherapy-induced ovarian failure in two open trials (Stearns et al. 2000 Weitzner et al. 2002) for a review, see Bordeleau et al. 2007) and in a double-blind study (Stearns et al. 2005). Paroxetine CR (25 mg day) was subsequently found to be efficacious in treating perimenopausal hot flashes in a placebo-controlled trial (Stearns et al. 2003). The drug's usefulness in this setting is underscored by recent concerns about the safety of hormone replacement therapy (HRT), hitherto the treatment of choice (H. D. Nelson et al. 2002). For clinicians and patients concerned about the long-term consequences of estrogen replacement in treating hot flashes, paroxetine provides a reasonable alternative.

Ginsengasian Panax ginseng Ginsana G115 Korean red ginseng

Promoted to improve vitality and well-being 200 mg PO daily. Ginsana 2 caps PO daily or 1 cap PO bid. Ginsana Sport 1 cap PO daily. Preliminary evidence of efficacy for erectile dysfunction. Efficacy unclear for improving physical or psychomotor performance, diabetes, herpes simplex infections, cognitive or immune function. American College of Obstetrics and Gynecologists and North American Menopause Society recommend against use for postmenopausal hot flashes. Not by prescription. 2- -

Selective Estrogen Receptor Downregulators

Fulvestrant generally is well tolerated with the most common adverse events being nausea, asthenia, pain, vasodilation (hot flushes), and headache. Injection site reactions, seen in 7 of patients, are reduced by giving the injection slowly. In the study comparing anastrozole and fulvestrant, quality-of-life outcome measures were maintained over time with no significant difference between the drugs.

Serm And Antiestrogen Products

Tamoxifen, A-dimethylethanamine (Nolvadex), is a triphenylethylene SERM used to treat early and advanced breast carcinoma in postmenopausal women. Tamoxifen is used as adjuvant treatment for breast cancer in women following mastectomy and breast irradiation. It reduces the occurrence of contralateral breast cancer in patients receiving adjuvant tamoxifen therapy. It is also effective in the treatment of metastatic breast cancer in both women and men. In premenopausal women with metastatic breast cancer, tamoxifen is an alternative to oophorectomy or ovarian irradiation. Tamoxifen can be used preventa-tively to reduce the incidence of breast cancer in women at high risk. Antiestrogenic and estrogenic side effects can include hot flashes, nausea, vomiting, platelet reduction, and (in patients with bone metastases) hypercalcemia. Like all triphenylethylene derivatives, it should be protected from light.

Paroxetine Introduction

Paroxetine (Paxil) is classified as one of the serotonin reuptake inhibitors (SRIs) because of its potent inhibition of presynaptic serotonin (5-HT) uptake. It is also a relatively potent norepinephrine (NE) reuptake inhibitor, particularly at higher doses, leading some to argue for its inclusion in the growing class of acknowledged dual serotonin-norepinephrine reuptake inhibitors (SNRIs). Since its approval for the treatment of depression, paroxetine has been demonstrated to be effective and has been approved for a broad spectrum of anxiety disorders, including panic disorder, obsessive-compulsive disorder (OCD), social anxiety disorder, generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD). Moreover, studies have demonstrated the efficacy of paroxetine in premenstrual dysphoric disorder (PMDD), postmenopausal hot flashes, and child and adolescent OCD and social anxiety disorder. Paroxetine is still one of the most prescribed antidepressant medications in the...

Pharmacotherapy Of Anxiety

Superior to fluoxetine, and both duloxetine and venlafaxine also may be effective) fibromyalgia peptic ulcer and irritable bowel syndrome hot flashes of menopause chronic fatigue cataplexy tics migraine and sleep apnea. These disorders may have some psychobiological relationship to mood or anxiety disorders.

Treatment Of Vasomotor Symptoms Of Menopause And Atrophic Vaginitis

Estrogens have been very useful in treating the hot flashes associated with early menopause, as well as atrophic vaginitis and other vaginal symptoms of inadequate estrogen production. The evidence that they result in enhanced mood and improved cognitive function in post-menopausal women is less clear, however, and more studies are needed to sort out the competing claims in these areas.102,103 Based on the results of the Women's Health Initiative (WHI) studies of HRT, however, the lowest effective doses should be used for as short of a duration as necessary for the management of postmenopausal symptoms (see below).

Therapeutic Uses

The major therapeutic use of clonidine (catapres, others) is in the treatment of hypertension (see Chapter 32). Clonidine also has apparent efficacy in the off-label treatment of a range of other disorders reducing diarrhea in some diabetic patients with autonomic neuropathy treating and preparing addicted subjects for withdrawal (see Chapter 23) ameliorating some of the adverse sympathetic nervous activity associated with withdrawal, and decreasing craving for the drug. Transdermal administration of clonidine (catapres-tts) may be useful in reducing the incidence of menopausal hot flashes.


EGFR less than 10mL minute 1.73m2 Pregnancy see notes above Breast-feeding see notes above Side-effects see notes above also ileus, dry mouth tachycardia, palpitation, arrhythmias, angina, transient ischaemic attacks, cerebral haemorrhage, myo-cardial infarction, syncope dyspnoea, bronchitis asthenia, nervousness, sleep disturbances hot flushes alopecia, sweating, skin reactions including Stevens-Johnson syndrome, toxic epidermal necro-lysis, and psoriasis-like efflorescence Dose


Augmentation therapy for women during these stages of life. Perimenopause is the phase before menopause, which continues until menstruation has ceased for 12 consecutive months. Common symptoms include hot flashes, decreased libido, sleep disruption, and depression. In one study, perimenopausal women with major depression, dysthymic disorder, or minor depressive disorder received transdermal patches of 17 b -estradiol (100 mg) or placebo in a 12-week study (336). Sixty-eight percent of women treated with estradiol had remission of depression compared to 20 in the placebo group (336). An earlier study also found that estrogen was superior to placebo in reducing depressive symptoms in perimenopausal women (337). A small study of 16 perimenopausal women found that estrogen replacement therapy was effective in treating depression (338). Other studies have found that both transdermal patches and sublingual estradiol improved mood in women with premenstrual dysphoric disorder and postpartum...

Raloxifene Oh

Tamoxifen exhibits antiestrogenic, estrogenic, or mixed activity depending on the target gene measured. Tamoxifen inhibits the proliferation of cultured human breast cancer cells and reduces tumor size and number in women, yet it stimulates proliferation of endometrial cells. The drug has an antiresorptive effect on bone and decreases total cholesterol, LDL, and Lp(a) but does not increase HDL and triglycerides. Tamoxifen approximately doubles the relative risk of deep vein thrombosis and pulmonary embolism and endometrial carcinoma. Tamoxifen produces hot flashes and other adverse effects, including cataracts, nausea, and hepatic steatosis. Due to its agonist activity in bone, it does not increase the incidence of fractures. Raloxifene is an estrogen agonist in bone and reduces the number of vertebral fractures by up to 50 in a dose-dependent manner. The drug also acts as an estrogen agonist in reducing total cholesterol and LDL but does not increase HDL or normalize...


Behavior, and in the treatment of menopausal vasomotor symptoms (''hot flushes'') 110 . Other potential uses are in neuroprotection, in the reduction of body weight, or in the treatment of depression and various types of dementia, including Alzheimer's disease 108, 111, 112 . Alzheimer's disease, which still has no specific cure, results in progressively worsening symptoms that range from memory loss to declining cognitive ability. It affects an estimated 10 of the population older than 65 years of age and almost 50 of those older than 85 years of age 113 .

Soy Isoflavones

Soy-rich diets have been credited with the low incidence of breast, stomach, and prostate cancers in Asian populations compared with their much higher prevalence in the Western hemisphere, where soy consumption is low.139 There has been a multifold increase in research studies correlating consumption of soybean products to prevention of breast, colon, uterine, and prostate cancers. Soy was found to be one of the potent natural supplements with cancer-prevention properties.140 It is a host of two important isoflavones, namely genistein and daidzein. These substances are shown to have various anticarcinogenic properties, including prevention of oxidation, inhibition of protein tyrosine phosphorylation, triggering of apoptosis, regulation of gene transcription, modulation of transcription factors, antiangiogenesis, and inhibition of DNA topoisomerage.141 Daidzein and genistein down-regulate the expression of prostate androgen-regulated transcript-1 (PART-1) gene, a possible prostate...

Menopausal Symptoms

One of the most disruptive and classic aspects of the menopause is the hot flash. In Western societies, it is the most common symptom of the menopause, although the prevalence is much lower in Japan 165,166 . This and the rarity of the problem in soybean-consuming populations have prompted investigations to determine whether phytoestrogens have a similar effect. Hormone replacement therapy (HRT) generally alleviates the hot flashes, as well as the vaginitis occurring at the menopause due to atrophy. More recently, postmenopausal Hot flashes are related to the fall in circulating estrogen, rather than absolute levels, and are associated with surges of gonadotropins from the pituitary, e.g., LH. As ovarian activity declines during menopause, serum estrone and E2 fall and remain low. It has been hypothesized that phytoestrogen consumption, due to ER binding affinity, may exert an estrogenic effect in the postmenopausal woman. Japanese women are reported to have a lower frequency of hot...