Examples Of New Targetdirected Drug Therapies

Drug development based on target-oriented approaches is now routine. Still, the development of a new drug can take a decade from the discovery of a 'lead compound' to routine clinical use. So, in oncology relatively few 'novel' drug are already being used in everyday practice, although many clinical studies are underway (Table 22.4). The experience obtained from the use of these novel drugs in clinical routine most clearly illustrates both the potential and limitations of target-oriented therapies in oncology.

Table 22.4. Selected targeted drugs employed in the clinic or clinical trials

Drug(s) Target(s) Stage of development

Table 22.4. Selected targeted drugs employed in the clinic or clinical trials

Drug(s) Target(s) Stage of development

Imatinib

BCR-ABL, KIT, PDGFR(?)

routine use

Farnesyl transferase

RAS (RHO?, RAC?)

clinical trials

inhibitors

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