Lkb1

19p13.3

mitotic control

intestine

BRCA1 is a «100 kb gene at chromosome 17q21 comprising 24 exons (Figure 18.6). Exon 11 of the gene is unusually large extending over >4.5 kb and accordingly contains a large part of the coding sequence. The BRCA1 protein consists of 1863 amino acids. Several centrally located nuclear localisation signal sequences identify it as a nuclear protein. There are several protein-protein interaction domains, including a RING-finger domain near the N-terminus. Near the C-terminus are two copies of a 110 amino acid sequence called BRCT motif. This iuvuuumiuij

0 0

Post a comment