Negative feedback control of hormone release

In many cases, hormones released from the adenohypophysis are part of a three-hormone axis that includes the:

• Hypothalamic hormone

• Adenohypophyseal hormone

• Endocrine gland hormone

The hypothalamic hormone stimulates or inhibits the secretion of the adenohypophyseal hormone. The trophic hormone from the adenohypophysis then stimulates the release of a hormone from another endocrine gland. This final endocrine gland hormone not only carries out its effects on its target tissues, it may also exert a negative feedback effect on the release of the hypothalamic and/or adenohypophyseal hormones. In this way, this final hormone regulates its own release (see Figure 10.3). This process is referred to as long-loop negative feedback. The adenohypophyseal hormone may also exert a negative feedback effect on the hypothalamic hormone and limit its own release. This process is referred to as short-loop negative feedback.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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