Physiological implications of modulation of nmda receptor function by ethanol

It is well known that the NMDAR plays a key role in long-term potentiation (LTP) of the AMPAR-mediated synaptic response, which is a cellular model of learning and memory.3,4 As expected, inhibition of NMDARs by ethanol was reported to also block hippocampal LTP,96-98 which was more pronounced in juvenile rats (30 days old) than in adult rats (90 days old).99 In addition, such inhibition has also been observed in vivo. Givens et al. reported that in awake rats, LTP was produced by stimulation...

Associated with ethanol exposure

The NMDAR has been linked to many behavioral paradigms associated with ethanol exposure such as intoxication, reward, sensitization, and relapse.6123 Below is a summary of some of the studies linking the NMDAR to ethanol-associated behavioral paradigms in vivo. Ethanol intoxication is measured in rodents by the length of sleep time upon systemic injection of hypnotic doses (3-4 g kg) of ethanol. Miyakawa et al. showed that Fyn deletion mice were more sensitive to intoxicating doses of ethanol...

References

Abe, T. et al., Fyn kinase-mediated phosphorylation of NMDAR NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain, Eur. J. Neurosci., 22, 1445, 2005. 2. Abraham, W.C. and Bear, M.F., Metaplasticity the plasticity of synaptic plasticity, Trends Neurosci., 19, 126, 1996. 3. Ali, D.W. and Salter, M.W., NMDAR regulation by Src kinase signalling in excitatory synaptic transmission and plasticity, Curr. Opin. Neurobiol., 11, 336, 2001. 4. Amadio, M., Battaini, F., and Pascale, A.,...

Nmda Receptor Phosphorylation In Central Nervous System Pathology

Adaptive plasticity that underlies physiological processes such as learning and memory requires a correct level of NMDAR activity to appropriately modify synaptic transmission. Conversely, maladaptive plasticity underlying disorders characterized by pathological hyperexcitability such as epilepsy or pain may result from excessive activity of NMDARs. Excessive NMDAR activity may also contribute to neuronal cell loss in CNS ischemia and neurodegenerative disorders. However, pathologically...