Personal Foreword

The idea to write a state-of-the-art monograph examining manifold aspects of lipophil-icity was born at the 7th European QSAR Symposium in Interlaken (1988). The Organizing Committee suggested that the spared funds of the Symposium be utilized for organizing a workshop on lipophilicity which would establish a solid base for such a monograph, and challenged us to undertake the task. It took us six long years to fulfill the first part of our commitment. The Symposium on Lipophilicity in Drug Research and Toxicology was held in Lausanne in March 1995, and was only possible thanks to an additional support by numerous companies and organizations. The remaining task turned out to be even more difficult. To publish a book so specified meant to ask a number of authors for collaboration. The our great joy, the majority of the contacted persons accepted, wrote their chapters, and even delivered their manuscript in time. We thank them for their collaboration.

However, editing is a thankless task. The text of any book of this series should be generally comprehensible, thus assuming a more or less consistent style. In trying this, editors are put under pressure by both authors and publisher, for different reasons. On top of it, there are also series editors who have firm and generally justified notion about the style of the entire book series. There is also a different degree of bias by individual partners: in our estimate the highest one with the authors, who usually present their favorite child with a great deal of an understandable enthusiasm, and the lowest one with the publishers who ist obliged to consider - and to foresee - the general success of the publication. Editors and series editors may find themselves somewhere half-way in between. Provided that the final outcome does not have a character of conference proceedings, the editors are compelled to set up basic style rules, and to exercise a certain pressure on the authors to follow them. In most instances, this was benevolently understood and respected.

The book contains, besides purely methodological contributions and established physico-chemical concepts, also chapters which my seemingly touch the problem of lipophilicity only from afar, or which may rather be considered as dreams of the future. However, we are conviced that they have a rightful place in this book.

There are many persons, in additions to the participating authors, to whom we owe our thanks. To name only very few of them, Professor Jean-Luc Fauchere gave the spiritual, and also material, impulse to this book. The VCH editors, Dr. Thomas Mager and Dr. Michael Bär carried out all the burdens asociated with the preparation for printing and manufacturing. And our colleagues, the series editors Professors Raimund Mannhold, Hugo Kubinyi, and Hendrik Timmerman, were most helpful with their critical comments.

February 1996

Zürich Vladimir Pliska

Lausanne Bernard Testa

Basel Han van de Waterbeemd

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