Assessment of DistributionpH Profiles

Alex Avdeef

Abbreviations

Pg

Prostaglandin, anion

Cpz

Chlorpromazine, free base

M

Morphine

M3G

Morphine-3ß-D-glucuronide

M6G

Morphine-6ß-D-glucuronide

Glu

/V-methyl-ü-glucamine, free base

Ibu

Ibuprofen, anion

DOPC

Dioleylphosphatidylcholine

eggPC

Egg phosphatidylcholine

Symbols

D

Lipid-water distribution pH-dependent function (also called the apparent

partition coefficient, PC.dpp), usually expressed in logarithmic (base 10) form

as log D

P

Lipid-water pH-independent partition coefficient (sometimes called K0VI or

PC), usually expressed as log P

Ke

Extraction constant

pKa

Ionization constant (negative log form)

Po

Apparent ionization constant in an octanol/water titration

"Scherrer" pKa (also p0A^alin'), the limiting p0Ka in titrations with very high

octanol/water volume ratios

ß

Cumulative stability constant

ñH

Bjerrum "difference" function

pH

operational pH scale

pcH

pH scale based on hydrogen ion concentration

AlogP

Difference in log P between neutral and ionized species

log p

Micro partition constant

0 0

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