Intramolecular Interactions Affecting Lipophilicity

Functional groups in solute molecules interact with each other in a number of ways depending on their own electronic and steric properties, on the number and nature of interconnecting bonds, and on intramolecular distances. Schematically, a number of dichotomic distinctions can be made, e.g., electronic versus steric effects, or through-bond versus through-space interactions. However, such distinctions may be misleading since they tend to neglect overlaps and intermediate cases. The headings and subheadings in this section present one possible classification in which intramolecular interac tions are considered first for themselves (sections 4.3.1-4.3.3), and then as influenced by isomerism and other aspects of molecular polymorphism (section 4.4).

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