Lipophilicity in Drug Action and Toxicology

edited by

Vladimir Pliska

Bernard Testa

Han van de Waterbeemd

Weinheim • New York • Basel • Cambridge • Tokyo

Series Editors:

Prof. Dr. Raimund Mannhold Biomedical Research Center Molecular Drug Research Group Heinrich-Heine-Universität Universitätsstraße 1 D-40225 Düsseldorf Germany

Volume editors: Prof. Dr. Vladimir Pliäka Department of Animal Science Swiss Federal Institute of Technology - ETH Zürich Tannenstr. 1 CH-8092 Zürich Switzerland

Prof. Dr. Hugo Kubinyi ZHVAV, A 30 BASF AG

D-67056 Ludwigshafen Germany

Prof. Dr. Bernard Testa University of Lausanne School of Pharmacy CH-1005 Lausanne Switzerland

Prof. Dr. Hendrik Timmerman Faculty of Chemistry Dept. of Pharmacochemistry Free University of Amsterdam De Boelelaan 1083 NL-1081 HV Amsterdam The Netherlands

Priv.-Doz. Dr. Han van de Waterbeemd

Hoffman-La Roche Ltd.

Pharma Research New Technologies

CH-4002 Basel

Switzerland

This book was carefully produced. Nevertheless, authors, editors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Published jointly by

VCH Verlagsgesellschaft mbH, Weinheim (Federal Republic of Germany)

VCH Publishers, Inc., New York NY (USA)

Editorial Director: Dr. Michael Bär

Production Manager: Dipl.-Wirt.-Ing. (FH) Bernd Riedel

Library of Congress Card No. applied for.

British Library Cataloguing-in-Publication Data: A catalogue record for this book is available from the British Library.

Deutsche Bibliothek Cataloguing-in-Publication Data: Lipophilicity in drug action and toxicology / ed. by Vladimir Pliäka ... - Weinheim ; New York ; Basel ; Cambridge ; Tokyo : VCH, 1996 (Methods and principles in medicinal chemistry ; Vol. 4) ISBN 3-527-29383-3 NE: Pliäka, Vladimir [Hrsg.]; GT

© VCH Verlagsgesellschaft mbH. D-69451 Weinheim (Federal Republic of Germany), 1996 Printed on acid-free and chlorine-free paper.

All rights reserved (including those of translation in other languages). No part of this book may be reproduced in any form - by photoprinting, microfilm, or any other means - nor transmitted or translated into machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law. Composition: Mitterweger Werksatz GmbH, D-68723 Plankstadt Printing: Strauss Offsetdruck GmbH, D-69509 Mörlenbach Bookbinding: Wilh. Osswald + Co, D-67433 Neustadt/Weinstr. Printed in the Federal Republic of Germany.

Distribution:

VCH, P.O. Box 10 11 61, D-69451 Weinheim (Federal Republic of Germany) Switzerland: VCH, P.O. Box, CH-4020 Basel (Switzerland)

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