Masking Agents

Masking agents, such as w-decylamine or N, /V-dimethyloctylamine in a concentration of 0.15 % (v/v), are often used to suppress interactions with free silanol groups on the solid phase. However, when the solute is an ionizable acid, ion pairs may be built with the masking agent. This results in higher than expected lipophilicities. It has also been proposed to add 0.25 % (v/v) 1-octanol to the mobile phase to mimic the octanol hydrogen-bonding activity [46]. Addition of small amounts of diethylamine may increase the measurable lipophilicity range up to the equivalent of log Poc[ = 8 [46],

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