Quadratic Function

On the basis of an extended solubility parameter model [44] Schoenmakers et al. [45] describe the relation between log k! and the fraction of the modifier (cp) in the binary solvent mixture by the following equation:

Log k„ values calculated according to Eq. (4) have been correlated with log Poct data by Braumann [27]. From these correlations it is concluded that, in the case of quite lipophilic compounds, the above approach yields overestimated kw. This observation also holds when using RM instead of log k' for the sake of RUvi calculations [24].

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