References

[1] van de Waterbeemd, H., and Testa, B.. Adv. Drug Res. 16, 85-225 (1987)

[2] ElTayar, N., Testa, B. and Carrupt, P. A., J. Phys. Chem. 96, 1455-1459 (1992)

[3] Meyer, H.,Arch. Exp. Pathol. Pharmakol. 42, 109-118 (1899)

[4] Overton, E., Studien ├╝ber die Narkose. Fisher: Jena 1901

[6] Leffler, J, E., and Grunwald, E., Rates and Equilibria of Organic Reactions, As Treated by Statistical, Thermodynamic and Extrathermodynamic Method Wiley: New York 1963, p. 22-27

[8] Zahradnik, R. and Chvapil, M., Experientia, 16, 511-512 (1960)

[9] Zahradnik, R., Arch. Int. Pharmacodyn. 85, 311-329 (1962)

[10] Hansch, C., and Fujita.T., J. Am. Chem. Soc. 86, 1616-1626 (1964)

[11] Hansch, C., and Leo, A., Substituent Constants for Correlation Analysis in Chemistry and Biology. Wiley: New York 1979

[12] Testa, B., and Kier, L. B., Med. Res. Rev. 11, 35-48 (1991)

[13] ElTayar, N.,Tsai, R. S.,Testa, B., Carrupt, P. A., and Leo, A., J. Pharm. Sei. 80, 590-598 (1991)

[14] Carrupt, P. A., Testa, B., Bechalany, A., El Tayar, N., Descas, P. and Perrissoud, D., J. Med. Chem. 34, 1272-1275 (1991)

[15] Glossary of Terms Used in Medicinal Chemistry, IUPAC, in press

[16] Glossary of Terms Used in Computational Drug Design, IUPAC, in press

[17] Rekker, R. F., The Hydrophobic Fragmental Constant. Its Derivation and Applications. A Means of Characterizing Membrane Systems. Elsevier: Amsterdam 1977

[18] Kier, L. B., Chen, C.-K.,Testa, B., and Carrupt, P.-A., Pharmaceut. Res. 12, 1-6 (1995)

Lipophilicity in Drug Action and Toxicology edited by Vladimir PliSka,Bernard Testa & Han van de Waterbeemd Copyright┬ę VCH Verlagsgesellschaft mbH,1996

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