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First edition 2010

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Cover Image: Two views of the X-ray crystallographic structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs at 5.5-A resolution (from Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H., and Noller, H. F. (2001) Science 292, 883-96 with permission). Perhaps Natures's most complicated molecular machine, the ribosome consists of RNA and proteins that work together to accomplish the multiple structural, catalytic, and force-generating steps required for the high-fidelity synthesis and elongation of polypeptides. Although the centerpiece of the 2009 Nobel Prizes in Chemistry, the ribosome remains a major challenge for enzyme scientists and kineticists seeking to unlock its many secrets.

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ISBN: 978-0-12-380924-7

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