C-3Ha are also relatively small, frequently necessitating the use of special techniques. Substitution by heavier isotopes can also give rise to a isotope effects, but they are frequently too small to be of great value in enzyme mechanistic work.

One of the main applications of secondary isotope effects is to distinguish Sn1 and Sn2 reactions. The a-kinetic isotope effect for Sn1 reactions is typically significantly larger than that observed in SN2-type reactions. Such behavior reflects changes in the geometry of the carbon atom undergoing substitution:

Healthy Chemistry For Optimal Health

Healthy Chemistry For Optimal Health

Thousands Have Used Chemicals To Improve Their Medical Condition. This Book Is one Of The Most Valuable Resources In The World When It Comes To Chemicals. Not All Chemicals Are Harmful For Your Body – Find Out Those That Helps To Maintain Your Health.

Get My Free Ebook

Post a comment