Recognizing that cooperative ligand binding is likely to be complicated, the English biophysicist A. V. Hill developed a simple "All-or-None" model to investigate the S-shaped oxygenation curve (Fig. 11.5) of hemoglobin.
FIGURE 11.5 Oxygen saturation curve for adult human hemoglobin in the presence of a physiologic bisphosphoglycerate (2 mM). Oxygen concentration is expressed as a partial pressure (units = mm Hg). Lung O2 concentration z 100 mm Hg; peripheral tissue O2 concentration z 30 mm Hg.
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