Ketogenic Diet in the 1990s

Jim Abrahams Epilepsy

Use of the ketogenic diet decreased greatly until it received national media attention in October 1994, when NBC-TV's Dateline aired a program on the treatment (7,8,42,63-66). This television program was based on the true story of Charlie, a 2-yr-old with intractable myoclonic, generalized tonic, and tonic-clonic seizures (Fig. 4). A videotape presentation made later summarizes Charlie's condition in 1994 Thousands Fig. 4. Charlie Abrahams, age 4, with his parents Jim and Nancy, as they...

Pathophysiological Events in Neuronal Network

Paroxymal Depolarising Shift

What is happening at the neuronal network level when neurons transition from their normal firing pattern to the interictal condition and then to the ictal state Figure 5B depicts some of the physiologic features that accompany these changes. Now, rather than recording electrical activity from the surface of the brain, single electrodes are placed inside individual excitatory cortical neurons 1 and 2, thereby recording intracellular potentials. Much of our understanding of epilepsy mechanisms...

Conclusion On Ketogenic Diet

We suggest that CR may underlie the anticonvulsant mechanism of the KD and that CR alone may be an effective antiepileptic diet therapy. Moreover, the anticonvulsant action of CR may operate through the combined effects of reducing blood glucose and elevating blood ketones, thereby modulating cerebral energy metabolism. Our preclinical findings in EL mice suggest that CR may be an effective dietary therapy for some human epilepsies because CR is easy to administer and is devoid of the adverse...