Comparison of CR and the KD on Epileptogenesis in EL Mice

We next compared the effects of CR with those of the KD on seizure susceptibility in juvenile EL mice, using our data and the previously published data of Todorova et al. (27) for the AL feeding of the KD. All the mice were matched for age, sex (male), and

Week of Treatment

Fig. 7. Influence of CR and the KD on seizure susceptibility in juvenile EL mice. The number of mice seizing was significantly lower in the CR and KD groups than in the AL group. From ref. 41, with permission.

Week of Treatment

Fig. 7. Influence of CR and the KD on seizure susceptibility in juvenile EL mice. The number of mice seizing was significantly lower in the CR and KD groups than in the AL group. From ref. 41, with permission.

body weight prior to the analysis (41). We found that the mild 15% CR diet was more effective than the KD in delaying seizure onset and in reducing seizure susceptibility (Figure 7). Our comparative analysis of CR and the KD was restricted to juvenile mice because the AL-fed KD does not inhibit seizure susceptibility in adult EL mice (74). In contrast to CR, which lowers blood glucose levels (Figure 5A), the AL-fed KD does not lower blood glucose levels in the juvenile EL mice (27).

The KD may inhibit epileptogenesis in the juvenile EL mice by prolonging the preweaning period, thereby causing the brain to metabolize ketones for energy (75,76). CR may enhance this effect by also lowering glucose levels. The AL-fed KD is ineffective in reducing seizure susceptibility in adult EL mice, in which glucose levels and body weights are not reduced (74). These findings suggest that the KD may be most effective in reducing seizure susceptibility when blood glucose levels or total calories are also restricted.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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