CR Reduces Plasma Glucose and Elevates OHB Levels

CR caused plasma glucose levels to drop significantly after one week in the 15% CR-fed juvenile mice (Fig. 5A). These levels remained significantly lower than those in the AL-fed mice throughout the study but increased gradually in the CR-fed mice after wk 5. In contrast to glucose levels, 15% CR caused plasma P-OHB levels to increase significantly in the juvenile mice (Fig. 5B). These levels were inversely related to those of glucose. In the adult EL mice, the decrease in plasma glucose levels was proportional to the degree of CR (Fig. 5C). As observed in the juvenile mice, the changes in plasma

Fig. 5. Influence of CR on plasma glucose and ß-OHB levels in juvenile (A, B) and in adult (C, D) EL mice. At least three animals were analyzed in each group except the adult 30% CR group, in which two animals were analyzed. Values are expressed as the mean ± SEM, or only as the mean for the adult 30% CR group. From ref. 41, with permission.

Fig. 5. Influence of CR on plasma glucose and ß-OHB levels in juvenile (A, B) and in adult (C, D) EL mice. At least three animals were analyzed in each group except the adult 30% CR group, in which two animals were analyzed. Values are expressed as the mean ± SEM, or only as the mean for the adult 30% CR group. From ref. 41, with permission.

glucose levels in the adults were inversely related to the changes in plasma P-OHB levels (Fig. 5D). These findings indicate that reductions in caloric intake cause inverse changes in plasma glucose and P-OHB levels in EL mice.

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