1. Berg JM, Tymoczko JL, Stryer L. Biochemistry, 5th ed. Freeman, New York, 2002.

2. Freeman JM, Kelly MT, Freeman JB. The Epilepsy Diet Treatment. Demos, New York, 1994.

3. Quant PA. The role of mitochondrial HMG-CoA synthase in regulation of ketogenesis. Essays Biochem 1994;28:13-25.

4. Rinaldo P, Matern D, Bennett MJ. Fatty acid oxidation disorders. Annu Rev Physiol 2002;64:477-502.

5. Nandi J, Meguid MM, Inui A, et al. Central mechanisms involved with catabolism. Curr Opin Clin Nutr Metab Care 2002;5:407-418.

6. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade. Cell 1995;83:835-839.

7. Foufelle F, Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002;366:377-391.

8. Hegardt FG. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J 1999;338:569-582.

9. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 1999;96:7473-7478.

10. Kliewer SA, Sundseth SS, Jones SA, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A 1997;94:4318-4323.

11. Kersten S, Mandard S, Escher P, et al. The peroxisome proliferator activated receptor a regulates amino acid metabolism. FASEB J 2001;15:1971-1978.

12. Steineger HH, Sorensen HN, Tugwood JD, Skrede S, Spydevold O, Gautvik KM. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxiso-mal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription Eur J Biochem 1994;225:967-974.

13. Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 Cells. J Biol Chem 2001;276:27950-27958.

14. Riu E, Ferre T, Mas A, Hidalgo A, Franckhauser S, Bosch F. Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism. Biochem J 2002;368:931-937.

15. Quant PA, Tubbs PK, Brand MD. Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme. Eur J Biochem 1990;187:169-174.

16. Rodriguez JC, Gil-Gomez G, Hegardt FG, Haro D. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem 1994;269:18767-18772.

17. Meertens LM, Miyata KS, Cechetto JD, Rachubinski RA, Capone JP. A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha. EMBO J 1998;17:6972-6978.

18. Kuo MH, Allis CD. Roles of histone acetyltransferases and deacetylases in gene regulation. BioEssays 1998;20:615-626.

19. Bough KJ and Eagles DA. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 1999;40:138-143.

20. Cullingford TE, Eagles DA, Sato H. The anti-epileptic ketogenic diet upregulates expression of the gene encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain. Epilepsy Res 2002;49:99-107.

21. Cullingford TE, Dolphin CT, Sato H. The peroxisome proliferator-activated receptor a-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. Neuropharmacology 2002;42:724-730.

22. Takada I, Yu RT, Xu HE, et al. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol Endocrinol 2000;14:733-740.

23. Cullingford TE, Dolphin CT, Bhakoo K, Peuchen S, Canevari L, Clark JB. Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic HMG-CoA cycle in CNS of suckling rat. Biochem J 1998;329:373-381.

24. Cullingford TE, Bhakoo KK, Clark JB. Hormonal regulation of the mRNA encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in neonatal primary cultures of cortical astrocytes and meningeal fibroblasts. J Neurochem 1998;71:1804-1812.

25. Cullingford TE, Bhakoo KK, Peuchen S, Dolphin CT, Patel R, Clark JB, Distribution of mRNAs encoding the peroxisome proliferator-activated receptor (PPAR) -a, -P, and -y and the retinoid X receptor (RXR) -a, -P, and -y in rat central nervous system. J Neurochem 1998;70:1366-1375.

26. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome prolifera-tor-activated receptors (PPARs): Tissue distribution of PPAR-a, -P, and -y in the adult rat. Endocrinology 1996;137:354-366.

27. Basu-Modak S, Braissant O, Escher P, Desvergne B, Honegger P, Wahli W, Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J Biol Chem 1999;274:35881-35888.

28. Singh I, Lazo O. Peroxisomal enzyme activities in brain and liver of pups of lactating mothers treated with ciprofibrate. Neurosci Lett 1992;138:283-286.

29. Padmini S and Rao PS. Enhanced beta-oxidative utilization of [1-14C]palmitate during active myelinogenesis in developing rat brain under nutritional stress. Lipids 1991;26:83-85.

30. Auestad N, Korsak RA, Morrow JW, Edmond J. Fatty acid oxidation and ketogenesis by astrocytes in primary culture J. Neurochem 1991;56:1376-1386.

31. Blazquez C, Sanchez C, Daza A, Galve-Roperh I, Guzman M. The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-acti-vated enzyme. J Neurochem 1999;72:1759-1768.

32. Blazquez C, Sanchez C, Velasco G, Guzman M. Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes. J Neurochem 1998;71:1597-1606.

33. Blazquez C, Woods A, de Ceballos ML, Carling D, Guzman M. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J Neurochem 1999;73:1674-1682.

34. Bixel MG, Hamprecht B. Generation of ketone bodies from leucine by cultured astroglial cells. J Neu-rochem 1995;65:2450-2461.

35. Daikhin Y, Yudkoff M. Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr 2000;130 (4S Suppl):1026S-1031S.

36. Yudkoff M. Brain metabolism of branched-chain amino acids. Glia 1997;21:92-98.

37. Dringen R, Gebhardt R, Hamprecht B. Glycogen in astrocytes: possible function as lactate supply for neighboring cells Brain Res 1993;623:208-214.

38. Cullingford TE, Bhakoo KK, Peuchen S, Dolphin CT, Clark JB. Regulation of the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in astrocytes and meningeal fibroblasts; implications in normal brain development and seizure neuropathologies. In: Quant PA, Eaton S (eds.). Current Views of Fatty Acid Oxidation and Ketogenesis—From Organelles to Point Mutations, Advances in Experimental Medicine and Biology. Kluwer/Plenum, New York, 1999, pp. 241-252.

39. Guzman M, Blazquez C. Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol Metab 2001;12:169-173.

40. Edmond J. Energy metabolism in developing brain cells. Can J Physiol Pharmacol 1992;70 (Suppl):S118-S129.

41. Sherwin AL. Neuroactive amino acids in focally epileptic human brain: a review. Neurochem Res 1999;24:1387-1395.

42. Yudkoff M, Daikhin Y, Nissim I, Lazarow, A, Nissim I. Ketogenic diet, amino acid metabolism, and seizure control. J Neurosci Res 2001;66:931-940.

43. Kish SJ, Dixon LM, Sherwin AL. Aspartic acid aminotransferase activity is increased in actively spiking compared with non-spiking human epileptic cortex. J Neurol Neurosurg Psychiatr 1988;51:552-556.

44. Yudkoff M, Daikhin Y, Nissim I, Grunstein R, Nissim I. Effects of ketone bodies on astrocyte amino acid metabolism J Neurochem 1997;69:682-692.

45. Erecinska M, Nelson D, Daikhin Y, Yudkoff M. Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J Neurochem 1996;67:2325-2334.

46. Scharrer E. Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 1999;15:704-714.

47. DeGiorgio CM, Schachter SC, Handforth A, et al. Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia 2000;41:1195-1200.

48. Lampen A, Carlberg C, Nau H. Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. Eur J Pharmacol 2001;431:25-33.

49. Maguire JH, Murthy AR, Hall IH. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur J Pharmacol 1985;117:135-138.

50. Lee SS, Pineau T, Drago J, et al. Targeted disruption of the alpha isoform of the peroxisome prolifera-tor-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome pro-liferators. Mol Cell Biol 1995;15:3012-3022.

Atkins Low Carb Diet Recipes

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