Hydrophilic Analogues

Water-soluble tocopherol analogues have also been made in order to utilize their efficient scavenging properties, but alter their distribution, especially in connection with treatment of oxidative stress during myocardial infarction. Trolox (312), the most well-known example, has a distribution coefficient (log D) of -1.02 (octanol/water, pH 7.4). It has been found to reduce infarct size in dogs subjected to myocardial ischaemia followed by reperfusion (Mickle et al., 1989). The hydrophilic (log P = -0.60) quaternary ammonium analogue MDL 73404 (313) has been found to have cardioselective distribu

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