nebivolol myocardial protective effects cannot be explained solely by the ß-blocking effect (Vandeplassche et al., 1988).
The thiol Captopril (647), an inhibitor of angiotensin-converting enzyme which reduces hypertension (Ondetti et al., 1977), possesses anti-inflammatory properties (Martin et al., 1984) and has been found to provide protection against reperfusion arrhythmias (vanGilst et al., 1986). Captopril has been reported to be a potent free radical scavenger, with a scavenging power as effective as superoxide dismutase against superoxide, as effective as dimethylthiourea against hydroxyl radical and better than allopurinol against HOC1 (Bagchi et al., 1986). The free radicals were generated from various biochemical systems (Das et al., 1987). More recently, it was reported that Captopril does not scavenge superoxide, and that it rather prevents superoxide production by chelating copper (Jay et al., 1991).
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