Acid and basic methacrylate polymers based on methacrylic acid and dimethylaminoethyl methacrylate were prepared and characterized by nuclear magnetic resonance spectrosocopy and dilute solution viscometry. Relations between pK3, pKb, pH, solubility and extent of ionization were determined by acid-base titration. Complex coacervates of these high charge density polymers were prepared and both yield and water content determined. Short-term cell viability using erythrocytes in these microcapsules was shown. The coacervates may be used for prostheses for organ transplant (Wen etal., 1991a).
In a second paper, Wen etal. (1991b) reported on the ionizable group content, structure, molecular weight, solubility, solution behaviour and efficacy of ionic complex formation through complex coacervation for a range of sparingly soluble synthetic weak polyelectrolyte polymers with low charge content based on hydroxyalkyl methacrylate. Selected polymers containing methacrylic acid and dimethylaminoethyl methacrylate showed promise as forming pairs for the entrapment of mammalian cells. The solubility of basic polymers was enhanced through quaternization of the TV-methyl group. The survival of guinea pig erythrocytes was indicated.
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