Dietary chemoprevention represents an attractive approach to this problem, especially given the young age of the patient population. Dietary supplements could be taken orally, which is certainly advantageous compared with the daily injections required with interferon therapy or direct injections of the lesions with steroids. Presumably, the side-effect profile would be minimal and certainly much more favorable than the fevers, irritability, growth disturbance, immunosuppression, and spastic diplegia (a form of cerebral palsy) associated with the other treatment options discussed in the previous section. Indeed, the EOMA model has proven efficacy to demonstrate the antiangiogenic properties of edible berry extracts and to explore the feasibility of dietary chemoprevention for endothelial cell neoplasms.40
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