In summary, the results of this foregoing study strongly suggest that oxidative stress and reactive oxygen species play a significant role in the cytotoxic effects of smokeless tobacco on hepatic mitochondria, microsomes, peritoneal macrophages, and cultured normal human oral keratinocyte cells.28'29'32'34■36-38'40'45'51'53 Modulation of Bcl-2 and p53 genes in human oral keratinocyte cells by STE plays a significant role in oxidative stress, leading to cell death and oral cancer.51 Furthermore, these results clearly demonstrate production of ROS oxidative DNA damage and enhanced intracellular oxidized states in NHOK cells in response to STE treatment, as demonstrated by cytochrome c reduction, increases in DNA damage with ladderlike fragmentation of genomic DNA, and increases in lipid peroxidation, ultimately leading to apoptotic cell death.28,29,40,53

Taken together, all of these cytotoxic effects leading to DNA damage and alterations in the expression of p53 and Bcl-2 in the presence of STE may constitute the defining stages of oral carcinogenesis and metastases.54-58

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment