Endothelial Cell Neoplasms As A Model Of Angiogenesis

Vascular tumors, especially endothelial cell neoplasms, are an excellent model that can be used to study the effects of antiangiogenic agents in vivo. Endothelial cell neoplasms are highly angiogenic, as the growth of these lesions entails endothelial cell proliferation, formation of luminal channels communicating with host vessels, and creation of perfused vascular spaces. The fact that humans with proliferating hemangiomas, a benign endothelial cell neoplasm, can have urinary bFGF levels elevated 25- to 50-fold higher than normal individuals attests to the degree of angiogenic activity associated with endothelial cell neoplasms.16 Halting the growth of these lesions requires the arrest of angiogenesis that is inherent in this process and is a direct indication of the antiangiogenic capabilities of the agent being tested. Several investigators have recognized this concept and used endothelial cell neoplasm models to evaluate the antiangiogenic effects of N-acetylcysteine, batimistat, IL-12, angiostatin, and AGM-1470.17-21

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment