Endothelial Cell Neoplasms As A Model Of Angiogenesis

Vascular tumors, especially endothelial cell neoplasms, are an excellent model that can be used to study the effects of antiangiogenic agents in vivo. Endothelial cell neoplasms are highly angiogenic, as the growth of these lesions entails endothelial cell proliferation, formation of luminal channels communicating with host vessels, and creation of perfused vascular spaces. The fact that humans with proliferating hemangiomas, a benign endothelial cell neoplasm, can have urinary bFGF levels elevated 25- to 50-fold higher than normal individuals attests to the degree of angiogenic activity associated with endothelial cell neoplasms.16 Halting the growth of these lesions requires the arrest of angiogenesis that is inherent in this process and is a direct indication of the antiangiogenic capabilities of the agent being tested. Several investigators have recognized this concept and used endothelial cell neoplasm models to evaluate the antiangiogenic effects of N-acetylcysteine, batimistat, IL-12, angiostatin, and AGM-1470.17-21

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