1

Proslaglandins

PïôlHeralifln Angiogencsis i

Phtagocylc aiiivatton

Phtagocylc aiiivatton

Proslaglandins

sunmfli apoptosis

Tumor progross^n

FIGURE 13.2 Free-radical-induced carcinogenesis and apoptosis. Free radicals can accelerate or inhibit carcinogenesis under different conditions. Free-radical-induced DNA damage and insufficient DNA repair can cause tumor progression, while inflammatory cytokines can stimulate p53, which causes growth arrest.

tocopherol, ascorbate, and P-carotene or by inducing endogenous antioxidant enzymes such as catalase, superoxide dismutase (SOD), thioredoxin, glutathione peroxidase (GPx), and reductase (GRS). Together, the antioxidant molecules and enzymes maintain an intracellular balance between reduction and oxidation.

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