Inflammation

Polymorphonuclear leukocytes (PMN or neutrophils) participate in the systemic immune system. Neutrophils are an integral part of the body's defense mechanism against pathogens and, upon activation, are recruited to the site of injury, where they produce superoxide anions the NADPH oxidase pathway.18,23 This enzyme is a multiprotein complex that is assembled upon PMN activation, and it reduces molecular oxygen (02) to the superoxide anion (^j Under inflammatory conditions, neutrophils also generate nitric oxide by both constitutive (nNOS) and inducible (iNOS) nitric oxide

94 Jpi synthases." At sites of inflammation, both NO and v i can be formed simultaneously, resulting in the generation of ONOO-.2425

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