Radionecrosis

Two comparative studies report benefit in patients with heavily damaged tissues. The first study tested preoperative hyperbaric oxygen against conventional penicillin cover in a randomized study of 74 patients requiring dental extraction following radical mandibular irradiation.38 Only 5.4% of the patients in the hyperbaric oxygen group, compared with 30% of the patients in the penicillin-treated group, experienced failure of wound healing 6 months after surgery (P<0.05). In 160 patients treated by hyperbaric oxygen or standard postoperative care following major soft-tissue surgery for radiotherapy injury, four-fold reductions in wound dehiscence, infection, and delayed wound healing were seen in the hyperbaric oxygen treated group (P<0.01).39 No adverse effects of hyperbaric oxygen were reported in either of these studies.

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