Silica Induces Dna Strand Breaks

DNA strand break (DSB) is probably one of the earliest types of genetic damage that occurs in cells exposed to silica. Using the alkaline DNA unwinding and ethidium bromide fluorometric techniques, Vallyathan and colleagues showed that crystalline silica induced DSB of bovine DNA.86 Silica-induced DNA damage in alveolar macrophages assayed using a single-cell gel electrophoresis Comet assay showed that N-acetylcysteine increased intracellular glutathione levels and protected against DNA strand breaks by inhibiting silica-induced ROS formation.87 In addition, exposure of Rat (RLE) and human (A549) epithelial cells to DQ12 quartz causes ^OH radical-dependent DNA lesions in cells.88 These studies firmly document that silica causes DSBs, which are driven by ^OH-radical-generating properties of the particles.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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