Marine Spindle Toxins As Potential Anticancer Drugs

Based on the successes and limitations of taxol as an anticancer drug, a number of tubulin-targeted marine toxins have been considered as a source of new anticancer drugs, some of which have entered clinical trials. The synthetic analogue of crypto-phycin 1, LY355703 ( cryptophycin 52), has entered phase II clinical trials (Sessa et al. 2002 Stevenson et al. 2002). Tasidotin, a dolastatin 15 derivative, entered phase I as a treatment for solid tumors (Ebbinghaus et al. 2005), while LU 103793...

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There has been a steady increase in the number of known marine toxins in the past few decades. The remarkable molecular diversity of these and other marine natural products probably exceeds the diversity of organisms that live in the sea. Earlier pioneering books on marine toxins such as those by Halstead (1965, 1967, 1970) and Hashimoto (1979) greatly stimulated scientific interest in toxins from marine animals and plants. In the past 30 years a major discovery has been that many of these...

References

Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA (2001) MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104 217-231. Abita JP, Chicheportiche R, Schweitz H, Lazdunski, M (1977) Effects of neurotoxins (veratridine, sea anemone toxin, tetrodotoxin) on transmitter accumulation and release by nerve terminals in vitro. Biochemistry 16 1838-1844. Aiyar J, Withka JM, Rizzi JP, Singleton DH, Andrews GC, Lin W, Boyd J,...

Neurotoxin From Conus Snails

Neurotoxin From Conus Snails

10.2 Peptide and Protein Toxins 10.2.1 Fish Integument Toxins Integumentary secretions of soapfishs, another teleost family, contain hemolytic peptides called grammistins (Hashimoto and Oshima 1972 Hashimoto 1979 Sugiyama et al., 2005). These are linear peptides of 12-28 residues that contain many basic amino acids and possess alpha-helical secondary structures. These peptides display antimicrobial activities against a wide variety of bacteria. Several grammistins were recently cloned (Kaji et...