The History Of Medicinal Chemistry

There is a long history of plants being used to treat various diseases. They figure in the records of early civilisations in Babylon, Egypt, India and China. The therapeutic properties of plants were described by the Ancient Greeks and by the Romans and are recorded in the writings of Hippocrates, Dioscorides, Pliny and Galenus. Some metals and metal salts were also used at this time. In the Middle Ages various 'Materia Medica and pharmacopeas brought together traditional uses of plants. The...

Drug Receptor Interactions

Although the Hansch reasoning does apply to the interaction of a drug with its receptor, many of the factors that are considered relate to the substance crossing barriers and entering different cellular phases. When we consider a drug interacting with a receptor or an enzyme system, there are a number of physico-chemical features that must be taken into account. A receptor or an enzyme system comprises a highly structured chiral environment dominated not just by the pockets created by the...