Structurally rigid groups

Groups that are structurally rigid are unsaturated groups of all types and saturated ring systems (Fig. 2.1). The former includes esters and amides as well as aliphatic conjugated systems and aromatic and heteroaromatic ring systems. The binding of these rigid structures ch3 h h ch

Selegiline (MAO inhibitor)

"C CH2CH2N(C2H5)2

1-Ethoxycarbonyl-2-trimethylaminocyclopropane (acetylcholine mimic)

N CH3

Procaine (local anaesthetic)

Acetylcholine

Figure 2.1 Examples of structural groups that impose a rigid shape on sections of a molecule. The shaded areas represent the rigid sections of the molecule h

to a target site can give information about the shape of that site as well as the nature of the interaction between the site and the ligand. Rigid structures may also be used to determine the conformation assumed by a ligand when it binds to its target site (see section 2.3.2). Furthermore, the fact that the structure is rigid means it may be replaced by alternative rigid structures of a similar size and shape to form analogues that may have different binding characteristics and possibly, as a result, a different activity or potency.

Insider Nutrition Secrets

Insider Nutrition Secrets

Secrets To Living Longer And Healthier Revealed By Nutrition Scientist! Insider Nutrition Secrets. Have you ever wondered what it might be like to find the long lost Fountain of Youth? We cant promise you that, but we can give you a close second. Starting today, learn the facts about what your body really needs to survive longer and healthier. Discover insider information from a former food and drug expert. Learn how a new food or drug is developed from the beginning until it finally reaches your grocers shelves.

Get My Free Ebook


Post a comment