AntiHIV Activity of Extracts and Compounds from Marine Algae

Se-Kwon Kim*'t'1 and Fatih Karadeniz*

Contents I. Background 256

II. Compounds from Marine Algae with

Anti-HIV Activity 257

A. Phlorotannins 257

B. Polysaccharides 259

C. Lectins 261

D. Other 262

III. Conclusion 263 References 263

Abstract In recent years, elucidation of novel bioactive substances from different marine organisms is gaining importance rapidly not only from the research and publications but also from controlled clinical studies of natural product-derived substances. They offer important leads for the development of antiviral drugs against viral infections caused by human immunodeficiency virus type 1 (HIV-1). Regarding this issue, numerous anti-HIV-1 therapeutic agents from marine resources have been reported for their potential medicine/medical application as novel functional ingredients in anti-HIV therapy. In detail, marine macroalgae have attracted much of attention as a reliable source for potential anti-HIV compounds. Up to date, several types of compounds such as tannins, polysaccharides, lectins, and derivatives have been isolated, identified, and reported to possess significant anti-HIV-1 activity.

* Department of Chemistry, Pukyong National University, Busan, Republic of Korea { Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea 1 Corresponding author: Se-Kwon Kim, E-mail address: [email protected]

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