Antiproliferativeantitumoranticancer activity

In recent years, it has been reported that fucose-rich sulfated polysacchar-ides isolated from brown seaweeds exhibited antitumor activity which is one of the most important biological activities of seaweeds.

Synytsya et al. (2010) demonstrated the antitumor activity of fucoidan from Undaria pinnatifida in PC-3, HeLa, A549, and HepG2 cancer cells in similar pattern to that of commercial fucoidan. In addition, fucose-rich sulfated polysaccharide of E. cava has antiproliferative effects on murine colon carcinoma (CT-26), human leukemic monocyte lymphoma (U-937), human promyelocytic leukemia (HL-60), and mouse melanoma (B-16) cell lines (Athukorala et al., 2009). Fucoidan was found to inhibit proliferation and induce apoptosis in human lymphoma HS-Sultan cell lines (Aisa et al., 2004). Further, they have reported the fucoidan-induced apoptosis was accompanied by the activation of caspase-3. In another recent study, antitumor and antimetastatic activities of fucoidan, isolated from brown seaweed Fucus evanescens, were studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma (Alekseyenko et al., 2007). Another in vitro study demonstrated the inhibitory effects of fucoidan on activation of epidermal growth factor receptor (EGFR) and cell transformation in JB6 C141 cells (Lee et al., 2008a). Their results provided the first evidence that fucoidan from Laminaria guryanovae exerted a potent inhibitory effect on EGF-induced phosphorylation of EGFR. The EGFR, one of the receptor tyrosine kinases, plays an important role in regulating cell proliferation, differentiation, and transformation (Chen et al., 1987). Therefore, it is an important target for cancer therapy (Yarden and Sliwkowski, 2001).

Antiproliferative and antitumor properties of fucoidan were reported for several studies (Itoh et al., 1995; Maruyama et al., 2003, 2006). Fucoi-dans inhibit tumor growth and metastatic process both by direct action on tumor cells and by the enhancement of immune response (Khotimchenko, 2010). Identification of novel effective cancer chemopreventive agents has become an essential worldwide strategy in cancer prevention (Eldeen et al., 2009). Therefore, finding of anticancer properties of brown algal fucoidans could elevate the value of brown seaweeds as functional ingredients in pharmaceuticals or functional foods.

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