Antiallergic effects

Allergic diseases are affecting approximately one-third of the general population in the world, and due to environmental changes and food habits, the prevalence and incidents of allergies are increasing. Wealth of research has been done to find antiallergic compounds, and phlorotan-nins or phlorotannin extracts from edible brown algae have shown promising potential in antiallergic therapy in vivo and in vitro models. Hyaluronidase enzyme is known to play an important role in allergic reaction, and Samee et al. (2009) have found that Sargassum tenerrimum phlorotannin extract is a strong inhibitor of hyluronidase (IC50 21 mg/ml). It is more potent than the commercially antiallergic drug disodium cro-moglycate (IC50 39 mg/ml) and almost similar to the natural inhibitor catachin (IC50 20 mg/ml). 6'6'-bieckol (Le et al., 2009), fucodiphloroethol G, and phlorofucofuroeckol A (Li et al., 2008) isolated from E. cava have also shown significant antiallergic activity by inhibiting histamine release by modulating the binding between IgE and FceRI receptors which mediate the allergen release in human basophilic leukemia (KU812) and rat basophilic leukemia (RBL-2H3). Further, Sugiura et al. (2007) have found the p-hexosaminidase enzyme (equivalent to histamine) inhibitory activity of phlorofucofuroeckol-B (IC50 7.8 pM) from brown alga Eisenia arborea which showed strongest inhibitory activity over antiallergic drug tranilast (IC50 46.6 mM) and epicatechin gallate (IC50 22 mM). And the presence of this very strong antiallergen would be the reason for shown in vivo antiallergic effects in brown Norway rats fed with dried E. arborea powder (Sugiura et al., 2008b).

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51 Ways to Reduce Allergies

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