Chapter

Marine Algae Possess Therapeutic Potential for Ca-Mineralization via Osteoblastic Differentiation

Minh Hong Thi Nguyen,*'t Won-Kyo Jung,*'t'1 and Se-Kwon Kim*'§

Contents I. Introduction 430

II. Therapeutic Potential of Marine Algae 432

A. Ca-mineralization via osteoblastic differentiation 432

B. Marine algae-derived biomaterials for bone tissue engineering applications 437

C. Marine algal diet with calcium supplement 438

III. Conclusion 438 Acknowledgments 439 References 439

Abstract One of the important natural product investigations from marine algae is to focus on the pharmaceutical^ important compounds that can be applied in bone health. Osteoporosis is one of the bone diseases caused by an imbalance between bone formation and resorption. Promotion of osteoblast differentiation is one of the best therapeutic ways to combat osteoporosis. Osteoblasts are the cells responsible for bone formation by increasing the proliferation of the osteoblastic lineage or inducing differentiation of the

* Department of Marine Life Science, Chosun University, Gwangju, Republic of Korea { Marine Bio Research Center, Chosun University, Gwangju, Republic of Korea { Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea } Department of Chemistry, Pukyong National University, Busan, Republic of Korea 1 Corresponding author: Won-Kyo Jung, E-mail address: [email protected]

Advances in Food and Nutrition Research, Volume 64 © 2011 Elsevier Inc.

ISSN 1043-4526, DOI: 10.1016/B978-0-12-387669-0.00033-8 All rights reserved.

osteoblasts. In this review, we describe the central effects of osteoblast differentiation by various bone therapy biomaterials from marine algae.

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