Phlorotannins and Fucoidans from Marine Macroalgae as Matrix Metalloproteinase Inhibitory Substances and Their possible Application as Medicinal Foods

Se-Kwon Kim,*'t'1 Noel Vinay Thomas,* and Xifeng Lit'*

Contents I. Introduction 130

II. Marine Algal Phlorotannins as Potential MMPIs 131

III. Marine Algal Fucoidans as Potential MMPIs 135

IV. Conclusions and Further Prospects 138 References 139

Abstract Metalloproteinases especially matrix metalloproteinases are a group of endopeptidases that contribute for the extracellular matrix degradation, and several tissue remodeling processes. Improper regulation of these endopeptidases could lead to several severe pathological problems that include cardiac, cartilage, and cancer-related diseases. Until now, many synthetic matrix metalloproteinase inhibitory substances (MMPIs) have been reported; however, many of them could not make to the final clinical trials.

* Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea

{ Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea { Department of Chemistry, College of Science, Yanbian University, Jilin, PR China 1 Corresponding author: Se-Kwon Kim, E-mail address: [email protected]

Advances in Food and Nutrition Research, Volume 64 © 2011 Elsevier Inc.

ISSN 1043-4526, DOI: 10.1016/B978-0-12-387669-0.00010-7 Ail rights reserved.

Hence, the emphasis on screening of MMPIs from different natural resources has gained much importance and marine resources are one among them. As marine organisms have been contributing with several biologically active compounds that have profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals; in this chapter, an attempt has been made to discuss the various MMPIs from edible seaweeds, which could be considered as medicinal foods.

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