Fucoxanthin isolated from L. japonica has been reported to suppress tyrosinase activity in UVB-irradiated guinea pig and melanogenesis in UVB-irradiated mice. Oral treatment of fucoxanthin significantly suppressed skin mRNA expression related to melanogenesis, suggesting that fucoxanthin negatively regulated melanogenesis factor at transcrip-tional level (Shimoda et al., 2010). Moreover, fucoxanthin has been demonstrated to possess photoprotective properties in human fibroblast cells via inhibition of DNA damage and enhance antioxidant activity (Heo and Jeon, 2009). These studies suggest that oral administration of fuco-xanthin might prevent or minimize the negative effects of UV radiation such as melanin formation.
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