Marine brown seaweeds are abundant in phlorotannins compared to other marine plants. These phlorotannins are a highly diverse group depending on their structure, and polymerizations and oligomers serve as most promising bioactive materials. Many reports have been published on strong activities of phlorotannin oligomers against oxidative stress, cancer, inflammation, allergy diabetes, and few other disorders in vitro and in vivo. Among them, E. cava has been studied extensively as it produces number of highly active phlorotannins. Phlorotannin derivatives are capable of modulating cellular signaling and thereby they regulate the adverse conditions of the body. Finally, it can be suggested that marine brown algal phenolic extracts or isolated phlorotannins should be developed as medicinal foods or therapeutics for human health applications.

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